Abstract: gsl@163.com Abstract：Objective To evaluate the effects of probucol combined with atorvastatin medication on blood levels of oxidized low-density lipoprotein (ox-LDL), lipoprotein-associated phospholipase A2 (Lp-PLA2), and the correlation of their changes in patients with acute coronary syndrome (ACS) undergoing percutaneous poronary intervention (PCI). Methods A total of 97 patients with ACS and undergoing PCI were randomly divided into two groups according to the date of admission: single medication group (n=42)， the patients were taken atorvastatin 20 mg/d; and combined medication group (n=55)， the patients were taken atorvastatin 20 mg/d with probucol 500 mg/d. The plasma levels of ox- LDL and Lp- PLA2 were measured in both groups before and 6-8 weeks after the medication. Then the results were compared and analyzed between two groups. Results (1) Before treatment there were no significant differences in levels of ox-LDL and Lp-PLA2 between two groups (P > 0.05). After the treatment, the ox-LDL level was significantly decreased in combined medication group (P < 0.01). After the treatment, the levels of Lp-PLA2 were significantly decreased than those before treatment in both groups (P < 0.01). Compared with single medication group, levels of ox-LDL and Lp-PLA2 were significantly lower in combined medication group (P < 0.01). (2) After treatment, the absolute value of Lp- PLA2 decline (ΔLp- PLA2) was positively correlated with the absolute value of ox- LDL decline (Δox- LDL) in combined medication group (r=0.314, P=0.020). Conclusion Probucol combined with statin therapy can reduce ox- LDL and Lp- PLA2 levels, and with a positive correlation between them. Probucol can further decrease the level of Lp-PLA2 by inhibiting ox-LDL production, which may be one of the mechanisms of its anti-atherosclerosis.

Key words: acute coronary syndrome, phospholipases A2, oxidative low density lipoprotein, Probucol, atorvastatin, antioxidant