Abstract: Objective To compare the differences between serum sclerostin levels in hyperthyroidism patients and euthyroidism healthy people. To explore the relationship between sclerostin levels and bone metabolism markers, BMD in hyperthyroidism patients. Methods Analyze sclerostin levels in 60 hyperthyroidism patients and 30 euthyroidism healthy people. 60 hyperthyroidism patients were divided into groups according to the T-score of their BMD. The bone metabolism markers and BMD were measured and the correlation between sclerostin and them was analyzed. Results The sclerostin levels in the hyperthyroidism group were higher than that in the euthyroid group(P＜0.01) . Among hyperthyroidism patients, the group with osteopenia or osteoporosis had a higher sclerostin, N-MID osteocalcin, total of type 1 collagen amino terminal extension of the peptide (tP1NP), beta collagen special sequence (P＜0.05) and a lower parathyroid hormone (PTH) (P＜0.05) compared to normal BMD group. Sclerostin was positively correlated with free triiodothyronine（FT3）and beta collagen special sequence and negatively correlated with PTH, total radius BMD, femoral neck BMD and lumber spine BMD in hyperthyroidism patients. Conclution Hyperthyroidism patients had a higher serum sclerostin levels, sclerostin is closely associated with abnormalities of bone metabolism.

Key words: Sclerostin, Hyperthyroidism, Bone metabolism, Osteoporosis