Abstract:

[Abstract] Objective To observe the association between adiponectin gene polymorphism, serum adiponectin lev? els with the incidence of coronary artery disease (CAD) and the severity of coronary artery stenosis in patients with essential hypertension (EH).Methods A total of414patients with EH (234cases with CAD and180cases without CAD) and185 control subjects were recruited in this study. Serum adiponectin levels were measured by enzyme-linked immunosorbent as? say (ELISA). Adiponectin single- nucleotide polymorphisms rs266729，rs7649121，rs1501299and rs3774262were geno? typed by polymerase chain reaction-restriction fragment length polymorphism (PCR-RFLP). Results Serum adiponectin levels were significantly lower in EH with CAD group than those in control group and EH without CAD group. Adiponectin SNP rs7649121AT genotype reduced the risk of CAD compared with AA genotype (adjustedOR=0.566，95%CI0.346-0.925，P=0.023). Logistic regression analysis showed that age and LDL-C were risk factors of CAD, and adiponectin was the protective factor for CAD in EH patients. The severity of coronary artery stenosis was negatively related to the level of adipo? nectin. Adiponectin levels were not affected by the adiponectin gene polymorphism.Conclusion The decreased serum adi? ponectin level was the independent risk factor for CAD in EH patients, which was negatively related to the severity of coro? nary artery stenosis. Adiponectin SNP rs7649121may contribute to the risk factors of CAD in EH patients.

Key words: Adiponectin, Polymorphisms, single-nucleotide, Coronary artery disease, Hypertension