Abstract: Objective: To investigate the relationship between changes of the plasma visfatin level and the other indexes of metabolic and biochemery in type 2 diabetes mellitus with or without nonalcoholic fatty liver disease.Methods: Plasma visfatin level were assayed by ELISA in all subjects.The relationship of plasma visfatin level with blood glucose、blood lipids、HbA1c、FINs、WHR、BMI、HOMA-IR were also analyzed. Results: Plasma visfatin level in the two groups of type 2 were significantly increased compared with controls. Plasma visfatin level was positively correlated with HOMA-IR、Fins、P2hBG and was positively correlated with HOMA-IR、Fins、FBG、 P2hBG、LDL.Multiple regression analysis showed that HOMA-IR、P2hBG、LDLwere independent related fators in influencing plasma visfatin level.Multiple regression analysis showed that HOMA-IR、P2hBG、LDL were independent related fators in influencing plasma visfatin level .Conclusion: The change of plasma visfatin level is associated with the sensitivity of insulin,which may contribute in part to the pathogenesis of type 2 diabete mellitus and nonalcoholic fatty liver disease.

Key words: visfatin, mellitus diabetes, type 2, nonalcoholic fatty liver disease