Abstract: [Abstract]   Objective   To investigate the changes of serum and urinary adiponectin (ADPN) levels and insulin resistance (IR) states in patients with chronic kidney disease (CKD) and to explore their relationship. Methods   487 patients with CKD stages 2-5 and 30 healthy subjects served as control group were enrolled in the study. ADPN levels in serum and urine samples were examined by ELISA and fasting insulin by radioimmunoassay. Blood routine test, liver and kidney functions, blood glucose, serum lipids, 24h urinary protein excretion and endogenous creatinine clearance rate were observed, and body mass index calculated. The differences of ADPN levels in serum and urine samples and homeostasis model assessment for insulin resistance (Homa-IR) were compared among the groups. Results   The serum and urine ADPN levels and Homa-IR in CKD patients were higher than those of the control group (P<0.05) and the worse of renal function, the higher of ADPN and Homa-IR levels (P<0.05). The CKD stages 3-5 patients with high Homa-IR had higher serum ADPN levels. The ADPN levels and Homa-IR were positively related to lipid parameters and 24h urinary protein, and negatively correlated with hemoglobin and serum albumin (P<0.05). Conclusion   CKD patients had higher ADPN level and more significant IR. The ADPN and IR were also correlated with serum lipids, hemoglobin, albumin and urinary protein. Dynamic monitor of ADPN level may have clinical significance in judging metabolic disorders in CKD patients.

Key words: kidney diseases, adiponectin, Insulin Resistence, lipids, Serum albumin, hemoglobins, urinary protein