Abstract:

[Abstract] Objective  To investigate the relationship between the 2 h plasma glucose level after oral glucose tolerance tests (2h-PG) and islet β-cell function and blood lipid in obese children. Methods  A total of 102 obese children aged 9-15 years were enrolled in this trial. Levels of fasting plasma glucose (FPG) in children were all lower than 5.6 mmol/L. According to 2 h-PG, subjects were divided into G1 (2 h-PG≤5.6 mmol/L) group，G2 (5.7~7.7 mmol/L) group and G3 (2 h-PG ≥7.8 mmol /L) group．The parameters related to glucose and lipid metabolism were compared between groups. The relationship between 2 h-PG and all indexes were analyzed. Results  Levels of glycosylated hemoglobin（HbA1c) and FPG were significantly lower in G1 group than those in G2 group and G3 group. Levels of fasting insulin (FINS), 0.5 insulin (0.5 h-INS) and insulin resistance index (HOMA-IR) were significantly higher in G3 group than those in G1 and G2 groups. The level of high-density lipoprotein cholesterol（HDL-c）was significantly lower in G3 group than that in G1 group. There were significant differences in 0.5 plasma glucose after oral glucose tolerance tests (0.5 h-PG), 2-hour insulin after oral glucose tolerance tests（2h-INS), low density lipoprotein cholesterol (LDL-c) and early insulin secretion index corrected by insulin resistance (IR-EIS) between three groups (P < 0.05 or P < 0.01). The level of 2 h-PG was positively related with HAb1c，FPG， 0.5 h-PG，0.5 h-INS，2 h-INS，HOMA-IR and LDL-c (P < 0.05 or P < 0.01)，but 2 h-PG was negatively related with IR-EIS (P = 0.002) after deduction of the effects of age and BMI. Multiple linear regression analysis showed that 2h-INS， FPG，FINS and IR-EIS were influencing factors of 2 h-PG. Conclusion  When 2 h-PG is higher than 5.6 mmol/L in obese children，there has been early islet β-cell function decline and dyslipidemias.

Key words: obesity children, 2 h plasma glucose level after oral glucose tolerance test, Islet β-cell function, Insulin Resistence, lipid