Abstract: Abstract:Objective　To investigate the expression of EBP50、AKT2in human breast cancer tissue, study their relationship with clinicopathological factor in breast cancer, and analyze their expression significance and their correlation with each other.Methods　The expression of EBP50、AKT2 in 56 cases of breast carcinoma and 30 cases of adjacent nontumor normal breast tissue was detected by SP immunohistochemistry. Results　①The postitive expression of EBP50、AKT2 in 56 cases of breast carcinoma were 30.36% and 76.79% respectively.There was a significant different between carcinoma and normal breast tissue(P< 0.05);②The overexpression of EBP50 in breast carcinoma had no relationship with the size of primary tumor, age and pathological type, but had some relationship with histological classification, clinical TNM staging, and lymph node metastasis (P<0.05); AKT2 expression was inversely correlated with lymph node metastasis (P<0.05), had no relationship with age, size of primary tumor, histological classification, clinical TNM staging and pathological type (P>0.05).③EBP50、AKT2 showed significant indirect correlation with each other invasive ductal carcinoma. Conclusion The overexpression of EBP50、AKT2 may play a important role in the carcinogenesis and progression of breast carcinoma. They may be as the indications of biological behavior and prognosis of breast carcinoma.

Key words: breast tumor, EBP50, AKT2, immunohistochemistry