Abstract: Abstract: Objective To investigate the expression and significance of proline-rich protein 11 (PRR11) in gallbladder carcinoma. Methods The expressions of PRR11 were detected by immunohistochemistry SP method in gallbladder carcinoma and paracancerous tissues of 58 patients and samples of 49 cases of chronic cholecystitis. The relationship between staining results and clinicopathological parameters (types of tissues, Nevein stage of gallbladder carcinoma, lymph node metastasis and tissue differentiation) of gallbladder cancer was analyzed. Results The positive expression rate of PRR11 protein in gallbladder carcinoma was 55.2% (32/58), which was much higher than that in the adjacent tissue (25.9%, 15/58) and chronic cholecystitis (4.1%, 2/49, P < 0.01). There were significant differences in expressions of PRR11 between different stages of Nevein, different degrees of tissue differentiation and with or without lymph node metastasis (P < 0.05), but there was no significant difference in expression of PRR11 between age, gender and tissue classification. Conclusion PRR11 protein is highly expressed in gallbladder carcinoma tissues, but weakly expressed or not expressed in paracancerous tissues and chronic cholecystitis tissues, suggesting that PRR11 may be involved in the occurrence, invasion and metastasis of gallbladder carcinoma.

Key words: gallbladder neoplasms, immunohistochemistry, proline-rich protein 11