Abstract: Abstract:Objective To investigate the expression and clinical significance of P-selectin in colorectal cancer cells. Methods The protein expression of P-selectin was detected by immunohistochemistry in colorectal cancer tissues (n=116) and corresponding non- tumor normal mucosa(n=57). The differences of P- selectin expression in colorectal cancer tissues, corre⁃ sponding non-tumor normal mucosa and the clinical pathological significance were compared and analysed in two groups. Results The expression of P-selectin protein was found not only in vascular endothelial cells but also in colorectal cancer cells. The positive rate of P-selectin expression was apparently higher in colorectal cancer cells (77.6%, 90/116) than that in normal mucosa (17.5%, 10/57, χ2=56.49, P ＜0.05). However, there were no significance in positive rates of P-selectin in colorectal cancer cells between tumors with different diameters, different degrees of differentiation, different depths of infiltration and with or without lymph node metastasis (80.6% vs. 74.1%, 79.0% vs. 74.3%, 78.4% vs. 76.9%, 82.7% vs. 73.4%, P＞0.05). Conclusion The high expression of P-seletin in colorectal cancer cells is an important characteristic of colorectal cancer.

Key words: colorectal neoplasms, P-selectin, immunohistochemistry, colorectal cancer