Abstract: Abstract Objective：To investigate the value of model for End-stage Liver Disease (MELD) score , MELD with incorporation of serum sodium(MELD-Na)score and the sequential organ failure assessment (SOFA) score for evaluation of prognosis of liver failure. Methods: A total of 290 consecutive patients with liver failure were included in the study and divided into two groups according to the prognosis .The MELD, MELD-Na and SOFA were calculated respectively and comparative analysis were performed . Areas under the receiver operating characteristic curve (AUC-ROC) of MELD , MELD-Na and SOFA were used to assess the prognosis of patients with LF . Results: The mortality of LF was 50.3% in this study. MELD, MELD-Na and SOFA were significantly higher in the death group than in the survival group (26.1±8.0 vs 20.2±5.0,33.1±12.4 vs 23.8±7.8, 9.7±2.9 vs 6.9±1.7, all p < 0.01). The area under curve （AUC）values generated by the ROC curves for SOFA score were higher （AUC=0.805）than those of MELD-Na score (AUC=0.732) and MELD score (AUC=0.714) respectively. The cut-off scores of three systems were 7.50, 28.14, 25.01 respectively, which could discriminate higher and lower mortality accurately. Conclusion：MELD,MELD-Na scores and SOFA have appreciable value to evaluate the prognosis of LF patients. SOFA is more accurate than MELD and MELD-Na scores in assessing prognosis of LF patients. Key words：liver failure1 prognosis2 MELD3 MELD-Na4 SOFA5

Key words: liver failure, prognosis, MELD, MELD-Na, SOFA