Abstract: Abstract Objective: To assess the value of serum lectin-like oxidized low-density lipoprotein receptor-1(LOX-1) in early prediction of acute coronary syndrome(ACS). Methods: Enzyme-linked immunosorbent assay was used to detect the level of serum LOX-1 in 75 patients who underwent coronary angiography, 22 normal control subjects, 28 with unstable angina(UA),25 with acute myocardial infarction(AMI). The SYNTAX score was calculated in all the 53 enrolled ACS patients, 19 patients with high SYNTAX score, 34 patients with low SYNTAX score. Results: The levels of LOX-1 was significantly higher in UA patients (86.08±29.93pg/ml )and AMI patients(103.93±36.53pg/ml) than in normal control subjects （66.78±23.49pg/ml ,P<0.01 or P<0.05).Furthermore, in AMI group, the levels of LOX-1 was significantly higher than in unstable angina group (P<0.05). Higher SYNTAX score was detected in AMI group (22.88±8.27) than in UA group(14.79±9.96, P<0.01). The levels of LOX-1 was significantly higher in patients with high SYNTAX score (107.43±35.18 pg/ml) than those with low SYNTAX score (86.90±31.27pg/ml，P＜0.05 ). Conclusion: LOX-1 might be a promising biomarker for predicting ACS.

Key words: Lectin-like oxidized low-density lipoprotein receptor-1, acute coronary syndrome, vulnerable plaque, SYNTAX score