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Efficacy of Isotretinoin in the treatment of severe acne

  

  • Received:2012-03-12 Revised:2012-09-27 Published:2013-02-15 Online:2013-02-15

Abstract: Tang zhiling,Dermatology department of Tianjin Jixian people's Hospital (301900) [Abstract] Objective To observe the efficacy of Isotretinoin in the treatment of severe acne . Methods The persons being tested were randomly divided into two groups , body weight ≥ 50kg in the test group, every other day took orally 10mg Isotretinoin , 3 times a day ; body weight <50 kg , every other day took orally 10mg Isotretinoin 2 times a day . Control group : 50mg minocycline hydrochloride twice daily . Treatment time of the both two groups of patients lasted for 8 weeks .At the 2th,4th and 6th week in the treatment and the 1th, 2th, 4th, 6th and the 8th week after the treatment, we compared efficiency scores respectively between the two groups of patients . Results At the 2th,4th,6th and the 8th week in the treatment , we compared the test group and the control group , the effective rate was significantly different . At the 4th and 6th week after the treatment,we compared the test group with the control group,the effective rate was still significantly different.Conclusions Isotretinoin in the treatment of severe acne was more effective than minocycline .

Key words: acne, severe, sotretinoin, efficacy