Abstract: Objective: To discuss the value of serum HE4 in the diagnosis of lung cancer.To analysis the level of HE4 in different pathological types and TNM staging lung cancer patients. Methods: Forty-seven patients with lung cancer and thirty-one healthy subjects were selected to join this study.According to pathological type and TNM stage grouping, non-parametric test was used to compare the differences of the each group serum HE4.In pathological diagnosis as the gold standard, draw ROC curve of serum HE4 and serum CEA for diagnosis of lung cancer. Results: There were significant differences in serum HE4 assay values between lung cancer group and healthy group, and lung cancer group were higher than healthy group.There were no significant differences in serum HE4 assay values among different pathological types and different TNM staging of lung cancer patients.The AUC of serum HE4 was closed to 1,and greater than the AUC of serum CEA. Conclusion: There were no significant differences in the level of serum HE4 among different pathological types and different TNM staging of patients with lung cancer. Serum HE4 is a specific and sensitive index in lung cancer，even better than serum CEA. The detection of serum HE4 is useful for the diagnosis of lung cancer.

Key words: lung cancer, HE4, CEA, diagnosis