Abstract: Objective To investigate the changed characteristics of oxygen dynamic and treatment Strategies of high altitude pulmonary edema(HAPE) patients with secondary acute respiratory distress Syndrome(ARDS)．Methods 8 HAPE with secondary ARDS patients data of oxygen dynamic were Monitiored with Swan-Ganz catheter；treatment methods were put forward． Results At the beginning Of monitor, the patients data of RAP、mPAP、PVRI、Qs/Qt increase significantly，cardiac output index（CI）、oxygen delivery（DO2）、oxygen consumption（V O2）、oxygen extraction rate（O2ext）、 PaO2／FiO２ decrease significantly；At the end of monitor, the patients data of RAP、mPAP、PVRI、Qs/Qt decrease significantly（P＜0.05），CI、DO２、VO２、O2ext、PaO2／FiO２increase significantly（Ｐ＜0.05），8 patients all survivaled．Conclutions HAPE with secondary ARDS patients data of hemodynamic、oxygen dynamic has disordered greatly．Therefore，early support of ventilation to improve hypoxia，enhance oxygen delivery is the most important treatment mesure.．

Key words: Acute high altitude edema, Acute respiratory distress syndrome, Oxygen dynamic, Monitior, Treatment