Abstract: 【ABSTRACT】Objective The aim of this study was to explore the treatment of renal sympathetic denervation for hypertension and discuss the relation between hypertension and sympathetic hyperactivity and endothelial function at the same time. Methods Eightheen mongrel dogs were studied as intervention (n=10) and control (n=8) groups. The intervention group was made the neurogenic hypertension model. Two groups received percutaneous catheter-based radiofrequency. Primary endpoints were changes of mean blood pressure (MAP) before and at 2, 4 and 10 weeks after procedure. The changes of endothelin-1 （ET-1）and calcitonin gene related peptide（CGRP）were detected at preoperation、after remolding and after procedure, and at the same time Ang II of intervention groups were also detected at 2, 6 and 10 weeks after procedure. We assessed the data changes effectiveness by repeated measures ANOVA. Results In intervention group, MAP、ET-1、CGR had changed significantly(P<0.01) after remolding, compared with baseline level, and MAP、 the level of ET-1、CGRP and AngII all changed significantly after catheter-based renal denervation (P<0.05) . Conclusion Sympathetic hyperactivity plays an important role in the progression of hypertension, and endothelial dysfunction happened in the development of hypertension. Renal sympathetic denervation causes substantial and sustained blood-pressure reduction, with Sympathetic hyperactivity reduced and the improvement of endothelial dysfunction at some degree.

Key words: Renal Sympathetic denervation, sympathetic hyperactivity, Hypertension, endothelial function