Abstract: Abstract objective：The goal of this study was relevance of AGEs in rat serum and periodontitis severity by detecting AGEs of diabetic periodontitis in the rat analysising the serum content of AGEs .Methods :Two-month-old male wistar rats (n=32)were randomly divided into four groups, the control group (N group), periodontitis group (P group), diabetic group( DM group), diabetic periodontitis group (DP group). Diabetic rats were induced by intraperitoneal injection of streptozotocin ( STZ) . Periodontitis rats were initiated by ligating floss around maxillary molars and High-sugar soft diet . Observation of rats in each group: body weight, food ,water, urine output, activities, periodontal index (periodontal pocket depth, gingival inflammation). Four and six weeks later, animals were sacrificed and the specimens were prepared for histological analysis. serum AGEs were measured in ELISA method. Results: Ligation in rats after four weeks and six weeks, there is more food and more drink urine to reduce the symptoms of the relative weight, blood glucose is greater than 16.7mmol / l.Rats in each group the value of periodontal pocket probing depth comparison between the two groups DP group and DM group, DP group and P group, DP group and N group, P group and DM group, P group and N group the difference were statistical significance (P <0.05).Serum AGEs in the DP group and N group, DP group and P group, DM group and P group, DM group and N group, statistically significant difference (P<0.05). Conclusion : It is relevant that Serum AGEs in diabetic rats and the severity of periodontitis.

Key words: diabetes, periodontitis, rat , AGEs, animal model