Abstract: [Abstract] Objective To explore value of myocardial enzyme， such as cardiac troponin I（cTn-I）, on diagnosis of cardiac insufficiency in patients with severe acute pancreatitis(SAP). Methods Fifty patients with severe acute pancreatitis from emergency, gastroenterology and Intensive Care Unit of our hospital were collected from 2008 to 2013. Serum biochemical markers, such as cTnI, myoglobin (MYO), Creatine kinase MB (CK-MB), lactate dehydrogenase (LDH) and aspartate aminotransferase (AST) were examined, APACHE Ⅱ score was also calculated. All patients were divided into two groups: cardiac insufficiency group and non-cardiac insufficiency group. The values of myocardial enzyme were compared using t test for normally distributed variables and rank-sum test for variables not normally distributed. The sensitivity and specificity of myocardial enzyme for cardiac insufficiency diagnosis in patients with SAP were evaluated using ROC cure. The relationship between myocardial enzyme and APACHE Ⅱ score was assessed by Pearson correlation coefficient. Results The level of cTn-I、LDH and AST in case of cardiac insufficiency group was significantly increased than that in case of non-cardiac insufficiency group（P ＜0.05）. The area under ROC curve for cTn-I was most large (0.940) than that for LDH (0.762) and AST (0.770). With a cut-off value of 0.07ng/ml, the sensitivity and specificity of cTn-I for diagnosing cardiac insufficiency in patients with SAP were 0.857 and 1.000, respectively. cTn-I was positively correlated with APACHE Ⅱ（P＜0.05）. Conclusion Serum cTn-I show the better ability in diagnosis of cardiac insufficiency, and can preferably reflect the severity of SAP.

Key words: severe acute pancreatitis, cardiac insufficiency, myocardial enzyme, cardiac troponin I