Abstract: [Abstract]  Objective   To compare the prognosis of patients with oral tongue cancer and the base of tongue cancer,and identify the prognostic factors. Methods   The patient records that were first accepted clinical treatments were collected.Patients were divided into oral tongue cancer group and the base of tongue cancer group, according to the tumor location. One hundred oral tongue cancer cases that were matched with fifty base of tongue cancer cases for gender, age, T-stage and tumor differentiation were simultaneously enrolled in the study. The survival rate and disease-specific survival rate were analyzed by Kaplan-Meier analysis. The multivariate analysis was conducted with the Cox regression model in two groups.Results   The three-year and five-year survival rates were 65% and 51% in oral tongue cancer group, and 40% and 28% in base of tongue cancer group. The three-year and five-year disease-specific survival rates were 61% and 46% in oral tongue cancer group, and 38% and 26% in base of tongue cancer group. There were significant differences in three-year and five-year survival rates and disease-specific survival rates between two groups (P＜0.05 or P＜0.01). Multivariate analysis showed that the recurrence (RR=1.431，P=0.019) and regional lymph node metastasis (RR=1.526，P=0.043) were prognostic risk factors.Conclusion   There was a better prognosis in tongue cancer group than that of the base of tongue cancer group. In the present study, the difference in prognosis was closely associated with the recurrence and regional lymph node metastasis in two groups. We concluded that the individual treatment should be used for patients with tongue cancer to improve prognosis.

Key words: tongue neoplasms, neoplasms, squamous cell, disease characteristics, mouth floor, prognosis, regression analysis, 随访研究