Abstract: Abstract： Metabolic markers were released in the process of bone resorption and formation during bone remodelling. These markers have been extensively studied in trials of osteoporosis and other metabolic bone disorders during the past de⁃ cades. Bone metabolic markers can replenish bone mineral density in the management of osteoporosis, but their use in clini⁃ cal practice is challenged by their variability. Recently, there are many great progress in research of bone metabolic markers application in non metabolic bone disorders.

Key words: osteoporosis, bone diseases, metabolic, review, bone turnover markers, variability