Tianjin Medical Journal

Tianjin Med J ›› 2015, Vol. 43 ›› Issue (5): 566-569.doi: 10.11958/j.issn.0253-9896.2015.05.030

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Progress in correlation of long non-coding RNA with breast cancer invasion and metastasis

SU Wei, ZHANG Jin△   

  1. The 3rd Department of Breast Cancer Tianjin Medical University Cancer Institute and Hospital; National Clinical Research Center of Cancer, Tianjin 300060, China; Tianjin Breast Cancer Prevention, Treatment and Research Center; Key laboratory of breast cancer prevention and therapy; Key Laboratory of Breast Cancer Prevention and Therapy, Tianjin Medical University, Ministry of Education, Tianjin 30060, China
  • Received:2014-10-11 Revised:2014-11-09 Published:2015-05-15 Online:2015-05-25
  • Contact: ZHANG Jin,E-mail: zhangjin@tjmuch.com E-mail:zhangjin@tjmuch.com
  • Supported by:
    Tianjin municipal Major Scientific and Technological Special Project for Significant Anticancer Development

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Abstract: Abstract:Long non-coding RNA(lncRNA) is a group of functional RNA molecules, which is more than 200 nucleotides in length and lacks ability of encoding protein. The current study indicates that the abnormal expression of lncRNA is closely related with breast cancer progression. Some lncRNA takes part in regulating the process of breast cancer invasion and me⁃ tastasis. This article reviews the abnormal expression of lncRNA in breast cancer and the relevance with breast cancer inva⁃ sion and metastasis, which is expected to provide new strategy for breast cancer diagnosis and treatment.

Key words: lncRNA, breast cancer, neoplasm invasiveness, neoplasm metastasis, molecular marker, review