Abstract: Peroxiredoxin 1（Prdx1）belongs to peroxide oxidoreductase protein（peroxiredoxin, Prdx）family，which is over-expressed in multiple cancers and it play an important role in antagonizing reactive oxygen species (ROS) therefore as works as anti-oxidations. Its expression is closely related with tumor proliferation, differentiation and metastasis as well as with sensibility to radiotherapy and chemotherapy. Its structure and biological function in tumors and regulation mechanism were reviewed in this paper. It can provide evidence to screen new therapeutic targets in the treatment of tumors.

Key words: Prdx1, peroxidase, neoplasms