Abstract: Chimeric antigen receptor (Car) T cells, not only have the characteristics of strong specific recognition of tumor antigens, but also have destruction and high affinity advantages, thus receiving more attention. Although it has played a lot of advantages in anti-tumor, it still has some shortcomings, which needs to be further optimized to improve the safety of its clinical application. In this study, The cell structure and biological function, treatment process, application development and application risk of Car T cells are reviewed, which provide references for further clinical immunotherapy of Car T.

Key words: Car T, cell therapy, neoplasms, review