Abstract: Objective To observe the treatment effects of trimetazidine on myocardial bridge. Methods A total of 76 patients with clinical symptoms, such as different degree of chest tightness, palpitations, breath shortness, chest pain, were diagnosed as coronary myocardial bridge by coronary angiography and divided into 2 groups randomly. While control group (n=40) were given beta-blockers or (and) calcium antagonistas routine treatment, treatment group (n=36) were given routine treatment and trimetazidine, 20mg every time, tid. Chest pain times per week, exercise tolerance, anxiety and depression scores, total ischemic burden in 24h and walking distance in 6min, were observed in 2 groups during follow-up of 12 weeks. Results Compared with control group, those of treatment group were all improved. Conclusion Treatment based on conventional treatment combined with trimetazidine is safe and effective, can further improve myocardial energy metabolism and exercise tolerance, improves the clinical effect and the life quality of patients

Key words: coronary artery disease, cardiomyopathies, trimetazidine, exercise tolerance, coronary myocardial bridge