关键词: 心房颤动, 综述, 一级预防, 血栓栓塞, 治疗, 肾素-血管紧张素-醛固酮系统, 心房重构

Abstract: Atrial fibrillation (AF) is one of the most common arrhythmias in clinical practice. It often causes serious thromboembolic complications, which brings great harm to human health. The incidence and morbidity rates of AF are increasing year by year. The research on the pathogenesis of AF has been focused on the aspects of electrical remodeling and structural remodeling. Atrial electrical remodeling and structural remodeling are the main mechanism of AF for the maintenance and recurrence. The intervention of atrial remodeling is helpful to the treatment of AF. It is found that the rennin-angiotensin aldosterone system (RAAS) plays an important role in atrial remodeling. RAAS blockers can significantly reduce the onset of AF by inhibiting the activation of the renin axis, which can block the activation of RAAS and improve the atrial remodeling. This may provide a new choice for the treatment of AF. This article reviews the research progress of RAAS blocking agent in the prevention and treatment of AF.

Key words: atrial fibrillation, review, primary prevention, thromboembolism, therapy, renin angiotensin aldosterone system, atrial remodeling