天津医药

天津医药 ›› 2018, Vol. 46 ›› Issue (11): 1189-1192.doi: 10.11958/20180961

• 临床研究 • 上一篇    下一篇

维生素D与社区获得性肺炎病情程度的相关性研究

齐丽△， 田永红   

  1. 天津市泰达医院急诊科 （邮编300457）
  • 收稿日期:2018-06-20 修回日期:2018-09-06 出版日期:2018-11-15 发布日期:2018-11-20
  • 通讯作者: 齐丽 E-mail:qili820125@aliyun.com

Association between vitamin D levels and the severity of community-acquired pneumonia

QI Li △, TIAN Yong-hong   

  1. Department of Emergency, Tianjin Economic-Technological Development Area Hospital, Tianjin 300457, China
  • Received:2018-06-20 Revised:2018-09-06 Published:2018-11-15 Online:2018-11-20

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摘要： 摘要： 目的 评估社区获得性肺炎 （CAP） 住院患者维生素D （Vit D） 缺乏情况， 探讨Vit D与CAP临床结果及严重程度的关系。方法 采用前瞻性观察研究， 选取2016年6月—2018年2月我院收治住院的CAP患者共96例。收集患者一般特征、 临床资料及入院48 h内生化指标， 根据血清25-羟维生素D ［25 （OH） D］ 水平分成3组： <10 µg/L组 （46 例）、 10~20 µg/L组 （30例） 及≥20 µg/L组 （20例）， 比较3组患者上述指标的差异， 应用Logistic回归探讨Vit D与CAP 病情程度的关系。结果 96例CAP患者中， Vit D缺乏 ［25 （OH） D<20 µg/L］ 患者76例 （79.2%）。高危CAP （CURB-65 分值3~5分） 患者中， Vit D重度缺乏 ［25 （OH） D<10 µg/L］ 的比例 （63.6%） 远高于低危 （CURB-65分值0~2分） 患者（39.7%）， 并且当血清25 （OH） D <10 µg/L时罹患高危CAP的风险是25 （OH） D≥20 µg/L患者的4.247倍 （95%CI： 1.041~17.337， P=0.044）。结论 CAP住院患者Vit D缺乏比例高， Vit D缺乏与CAP疾病严重程度相关， Vit D重度缺乏的CAP患者病情加重的风险明显增高。

关键词: 维生素D, 肺炎, Logistic模型

Abstract: Abstract: Objective To evaluate the serum vitamin D (Vit D) deficiency in hospitalized patients with community- acquired pneumonia (CAP), and to investigate its association with clinical outcomes and disease severity. Methods A total of 96 CAP patients admitted to our hospital from June 2016 to February 2018 were selected in this prospective study. The general characteristics, clinical data and biochemical indexes in 48 hours of admission were measured in 96 CAP patients. The patients were divided into three groups by serum levels of 25-hydroxyvitamin D ［25(OH)D]: <10 µg/L group (n=46), 10~ 20 µg / L group (n=30) and ≥20 µg / L group (n=20). All these indexes were compared between three groups. Logistic regression analysis was used to investigate the relationship between 25(OH)D and the severity of CAP. Results In total 96 CAP patients there were 76 patients (79.2%) with Vit D deficiency, [25(OH)D<20 µg/L]. Prevalence of severe deficiency of Vit D ［25(OH)D<10 µg/L］ was far more (63.6%) in high-risk CAP patients (CURB-65 score 3-5) than that of low-risk CAP patients (39.7%, CURB-65 score 0-2). And when serum 25（OH）D <10 µg/L, the risk of developing high-risk CAP was 4.247 times of those with 25（OH）D≥20 µg/L (95%CI:1.041-17.337， P=0.044). Conclusion Hospitalized CAP patients have low Vit D status, and which is associated with the severity of CAP. The risk of aggravation is significantly higher in CAP patients with severe Vit D deficiency.

Key words: vitamin D, pneumonia, Logistic models