天津医药

天津医药 ›› 2018, Vol. 46 ›› Issue (11): 1241-1245.doi: 10.11958/20180971

• 综述 • 上一篇    下一篇

原位自组装多肽在肿瘤和细菌感染诊断及治疗中的研究进展

张从柔， 黄帆， 刘鉴峰， 杨丽军△   

  1. 天津， 北京协和医学院&中国医学科学院放射医学研究所， 天津市放射医学与分子核医学重点实验室 （邮编300192）
  • 收稿日期:2018-06-20 修回日期:2018-10-08 出版日期:2018-11-15 发布日期:2018-11-20
  • 通讯作者: 张从柔 E-mail:congrouzhang@163.com
  • 基金资助:
    构建ROS响应的“OFF/ON”可控型F-19 MRI纳米探针用于肿瘤诊断;基于复合胶束的多功能纳米药物用于探索2型糖尿病的多靶点协同治疗;纳米医用材料;低能放射性核素标记及药物临床前药代动力学关键技术平台建设;放射性核素标记药物及临床前药代动力学关键技术研发;药物化合物库建设与开发利用

Research progress of in situ self-assembling peptides in diagnosis and treatment of tumors and bacterial infections

ZHANG Cong-rou, HUANG Fan, LIU Jian-feng, YANG Li-jun△   

  1. Tianjin Key Laboratory of Radiation Medicine and Molecular Nuclear Medicine, Institute of Radiation Medicine, Chinese Academy of Medical Sciences and Peking Union Medical College, Tianjin 300192, China
  • Received:2018-06-20 Revised:2018-10-08 Published:2018-11-15 Online:2018-11-20
  • Contact: Congrou ZHANG E-mail:congrouzhang@163.com

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摘要： 摘要： 肿瘤和细菌感染严重危害人类健康， 因此亟需开发有效的诊疗方法以克服这两类疾病。原位自组装多肽能够特异识别病灶部位某些特异性高表达的物质， 靶向性地在病灶部位聚集， 并通过自组装形成稳定的纳米结构，从而实现疾病的精确诊断和有效治疗， 并降低对正常组织的毒副作用， 是一种在疾病诊疗方面应用前景广阔的医用材料。本文就原位自组装多肽在肿瘤和细菌感染的诊断及治疗中的研究进展进行综述。

关键词: 肿瘤, 细菌感染, 诊断, 治疗, 原位自组装多肽, 诊疗一体化

Abstract: Abstract: Tumor and bacterial infections are seriously endanger human health. Therefore, it is urgent to develop effective theranostic methods to overcome these two types of diseases. In-situ self-assembling peptides can target to in-situ aggregation of lesions induced by certain specifically high-expressed substances at the lesion site and form stable nanostructures through self-assembly, thereby facilitating the accurate diagnosis and effective therapy of diseases. The therapeutic effect and the reduced toxic side effects on normal tissues make the in-situ self-assembling peptides a kind of medical material with broad application prospects in the diagnosis and treatment of diseases. This article reviews the research progress of in situ self-assembling peptides in the diagnosis and treatment of tumor and bacterial infections.

Key words: neoplasms, bacterial infections, diagnosis, therapy, in situ self-assembling peptide, theranostic