线粒体功能障碍与多囊卵巢综合征相关性的研究进展

doi:10.11958/20220686

天津医药 ›› 2022, Vol. 50 ›› Issue (12): 1330-1334.doi: 10.11958/20220686

线粒体功能障碍与多囊卵巢综合征相关性的研究进展

王立娜¹^,²(), 陈慧平³, 田文艳¹^,², 颜琪¹^,², 张慧英¹^,²^,^△()

1 天津医科大学总医院妇产科（邮编300052）
2 天津市生殖健康与优生重点实验室
3 天津市第四中心医院

收稿日期:2022-05-30 修回日期:2022-07-24 出版日期:2022-12-15 发布日期:2022-12-30
通讯作者: 张慧英 E-mail:wanglina9611@163.com;huiying_zhang2020@126.com
作者简介:王立娜（1996），女，硕士在读，主要从事妇科生殖和内分泌方面研究。E-mail：wanglina9611@163.com
基金资助:
国家自然科学基金资助项目(82171629);天津市科技计划项目(18ZXDBSY00220);天津市卫生健康科技项目(ZC20005)

Research progress on the relationship between mitochondrial dysfunction and polycystic ovary syndrome

WANG Lina¹^,²(), CHEN Huiping³, TIAN Wenyan¹^,², YAN Qi¹^,², ZHANG Huiying¹^,²^,^△()

1 Department of Obstetrics and Gynecology, Tianjin Medical University General Hospital, Tianjin 300052, China
2 Tianjin Key Laboratory of Reproductive Health and Eugenics
3 Tianjin Fourth Central Hospital

Received:2022-05-30 Revised:2022-07-24 Published:2022-12-15 Online:2022-12-30
Contact: ZHANG Huiying E-mail:wanglina9611@163.com;huiying_zhang2020@126.com

王立娜, 陈慧平, 田文艳, 颜琪, 张慧英. 线粒体功能障碍与多囊卵巢综合征相关性的研究进展[J]. 天津医药, 2022, 50(12): 1330-1334.

WANG Lina, CHEN Huiping, TIAN Wenyan, YAN Qi, ZHANG Huiying. Research progress on the relationship between mitochondrial dysfunction and polycystic ovary syndrome[J]. Tianjin Medical Journal, 2022, 50(12): 1330-1334.

摘要/Abstract

摘要：

多囊卵巢综合征（PCOS）是以生殖、内分泌和代谢异常为特征的常见疾病，其发病机制不明确。线粒体在能量代谢等多种生命活动中发挥关键作用，线粒体相关调控机制受损可导致其功能障碍，常见有线粒体基因组异常、能量代谢异常、氧化应激、钙稳态失衡、生物合成减少、细胞增殖凋亡失衡、线粒体动力学紊乱及自噬异常等。PCOS作为多种疾病的相关因素被广泛认可，线粒体基因调控和功能紊乱与PCOS的发生发展密切相关，基于线粒体功能修复的治疗方法是PCOS治疗的新方向。该文就线粒体功能障碍与PCOS相关性的研究进展进行综述。

关键词: 线粒体, 多囊卵巢综合征, 基因组，线粒体, 氧化性应激, 线粒体动力学, 自噬, 卵泡发育, 钙稳态

Abstract:

Polycystic ovary syndrome (PCOS) is a common disease characterized by reproductive, endocrine and metabolic abnormalities, and its pathogenesis is still unclear. Mitochondria play a key role in a variety of life activities such as energy metabolism. The impairment of mitochondrial related regulatory mechanisms can lead to its dysfunction, such as mitochondrial genome abnormalities, energy metabolism abnormalities, oxidative stress, calcium homeostasis imbalance, reduced biosynthesis, cell proliferation and apoptosis imbalance, mitochondrial dynamics disorder and autophagy abnormality. Mitochondrial dysfunction is widely recognized as a related factor of many diseases. Studies have confirmed that mitochondrial gene regulation and dysfunction are closely related to the occurrence and development of PCOS. The treatment method based on mitochondrial function repair is a new direction of PCOS treatment. This paper reviews the research progress of mitochondrial dysfunction and PCOS.

Key words: mitochondria, polycystic ovary syndrome, genome, mitochondrial, oxidative stress, mitochondrial dynamics, autophagy, follicle development, calcium homeostasis

中图分类号:

R711.75

参考文献 34

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线粒体功能障碍与多囊卵巢综合征相关性的研究进展

Research progress on the relationship between mitochondrial dysfunction and polycystic ovary syndrome

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