天津医药

天津医药 ›› 2016, Vol. 44 ›› Issue (9): 1095-1098.doi: 10.11958/20160243

• 临床研究 • 上一篇    下一篇

Stat1和MMP-2在胰腺癌中表达的意义

孙宁1,孙宇1,张宝帅2,杨绍时1   

  1. 天津医科大学第二医院外科（邮编 300211）
  • 收稿日期:2016-04-18 修回日期:2016-08-01 出版日期:2016-09-15 发布日期:2016-09-28
  • 通讯作者: 杨绍时 E-mail:yang631231@126.com
  • 作者简介:孙宁（1988）， 男， 住院医师， 硕士， 主要从事甲状腺乳腺及胰腺肿瘤方面研究
  • 基金资助:
    天津医科大学科研基金资助项目（2015KYZM13）

Significance and expression of STAT1 and MMP-2 in pancreatic carcinoma

SUN Ning, SUN Yu, ZHANG Baoshuai, YANG Shaoshi△   

  1. Department of Surgery, Second Hospital of Tianjin Medical University, Tianjin 300211, China
  • Received:2016-04-18 Revised:2016-08-01 Published:2016-09-15 Online:2016-09-28
  • Contact: YANG Shaoshi E-mail:yang631231@126.com

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摘要： 目的 探讨胰腺癌中信号转导子和转录激活子 1（STAT1）与基质金属蛋白酶（MMP）-2 表达的相关性及其临床意义。 方法 采用 SP 免疫组化染色技术检测 115 例胰腺癌中 STAT1 及 MMP-2 的表达情况， 并收集患者年龄、肿瘤大小、淋巴结转移、TNM 分期、分化程度及术后生存时间等临床资料。 结果 115 例胰腺癌中， STAT1 高表达 52 例， MMP-2 高表达 56 例， 不同临床分期、肿瘤分化程度以及淋巴结是否转移患者 STAT1 和 MMP-2 蛋白的表达差异有统计学意义（P＜ 0.05）。 STAT1 与 MMP-2 表达呈负相关（rs=-0.50， P＜ 0.01）。 有淋巴结转移、临床分期级别高、STAT1 低表达胰腺癌患者术后生存时间相对缩短。 结论 STAT1 低表达与 MMP-2 高表达在胰腺癌的进展中起重要作用。 STAT1 表达对于判断预后和指导治疗具有一定的临床价值。

关键词: 胰腺肿瘤, 基质金属蛋白酶 2, 免疫组织化学, 预后, STAT1

Abstract: Objective To investigate the expression and clinical significance of transcriptional activator (STAT) 1 and matrix metalloproteinases (MMP)- 2 in pancreatic cancer (PC). Methods The expressions of STAT1 and MMP- 2 weredetected by S-P immunohistochemical methods in 115 PC patients and whose age, tumor size, lymph node metastasis, TNM stage, differentiation and survival time were also collected. Results STAT1 protein was high expressed in 52 cases and MMP-2 was high expressed in 56 cases, which were significantly related with different clinical stages, tumor differentiation and lymph node metastasis in patients with PC (P＜ 0.05). STAT1 expression was negatively correlated with MMP- 2 expression (rs = - 0.50, P＜ 0.01). Lymph node metastasis, high level of clinical stage, low expression of STAT1 showed reduced postoperative survival time in patients with PC. Conclusion The lower expression of STAT1 and higher expression of MMP-2 play an important role in the progression of PC. The expression of STAT1 has practical value in the evaluation of prognosis in patients with PC ．

Key words: pancreatic neoplasms, matrix metalloproteinase 2, immunohistochemistry, prognosis, STAT1