天津医药

天津医药 ›› 2017, Vol. 45 ›› Issue (12): 1337-1340.doi: 10.11958/20170930

• 综述 • 上一篇    下一篇

miRNA-183 家族在恶性肿瘤中作用的研究

张自立 1， 王金亮 2， 孟祥朝 1△   

  1. 作者单位： 天津医科大学三中心临床学院普外科 （邮编 300170）； 2 河北省邢台市第三医院普外科 作者简介： 张自立 （1980）， 男， 硕士， 主治医师， 主要从事甲乳肿瘤基础及临床研究 △通讯作者 E-mail: mxc5168@sina.com
  • 收稿日期:2017-09-04 修回日期:2017-09-25 出版日期:2017-12-15 发布日期:2017-12-15
  • 通讯作者: 张自立 E-mail:18522090765doc@sina.com

Study on the role of miRNA-183 family in malignant cancer

ZHANG Zi-li1, WANG Jin-liang2, MENG Xiang-chao1△   

  1. 1 Department of General Surgery, the Third Central Clinical College of Tianjin Medical University, Tianjin 300170, China; 2 Department of General Surgery, Xingtai Third Hospital △Corresponding Author E-mail mxc5168@sina.com
  • Received:2017-09-04 Revised:2017-09-25 Published:2017-12-15 Online:2017-12-15

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摘要： miRNA 与恶性肿瘤密切相关， 作为一类新型的调节因子， miRNA 在肿瘤的发生和发展中起着重要作用， 扮演着癌基因或者抑癌基因的角色。miRNA 在肿瘤中存在异常表达， 且大多数异常表达的 miRNA 与肿瘤的分期、 恶性程度、 治疗、 预后等相关， 这为肿瘤的早期诊治及预后评估提供了新的策略。miRNA-183 家族由 miRNA-96、 miRNA-182 及 miRNA-183 三种 miRNA 组成， 在消化系统、 泌尿生殖系统、 呼吸系统等多种肿瘤中表达异常。关于 miRNA-183 家族与肿瘤关系之间的研究越来越多， 且已深入到机制方面的研究。

关键词: 微 RNAs, 乳腺肿瘤, 前列腺肿瘤, 肺肿瘤, 消化系统肿瘤, miRNA-183 家族

Abstract: MiRNAs have a close relation with the development of malignancy. As a new type of regulatory factor, miRNA plays an important role in the development and progression of tumors, and plays the role of oncogene or tumor suppressor gene. Abnormal expression of miRNA is found in tumors. Most of the abnormal expression of miRNA are related to tumor staging, malignancy, treatment and prognosis, which provides a new strategy for the evaluation of early diagnosis, treatment and prognosis of tumors. The miRNA-183 family is composed of three types of miRNAs including miRNA-96, miRNA-182 and miRNA-183. They present abnormal expressions in tumors of digestive system, urogenital system and respiratory system. More and more researches have been done on the relationship between miRNA-183 family and tumor, and the mechanism has been deeply studied.

Key words: microRNAs, breast neoplasms, prostatic neoplasms, lung neoplasms, digestive system neoplasms, miRNA- 183 family