小胶质细胞极化在神经病理性疼痛中作用研究进展

doi:10.11958/20240408

天津医药 ›› 2024, Vol. 52 ›› Issue (9): 1000-1003.doi: 10.11958/20240408

小胶质细胞极化在神经病理性疼痛中作用研究进展

陈晶晶¹(), 农章嵩², 谭良源¹, 杨培培², 梁英业², 唐宏亮³, 王开龙²^,^△()

1 广西中医药大学研究生院（邮编530000）
2 广西中医药大学第一临床医学院康复医学科
3 广西中医药大学附属防城港医院

收稿日期:2024-04-02 修回日期:2024-05-17 出版日期:2024-09-15 发布日期:2024-09-06
通讯作者: ^△E-mail：13707884976@163.com
作者简介:陈晶晶（1994），女，硕士在读，主要从事针灸推拿理论与应用研究。E-mail：672823332@qq.com
基金资助:
国家自然科学基金资助项目(82060902);广西自然科学基金资助项目(2020GXNSFBA297107)

Research progress on the role of microglia polarization in neuropathic pain

CHEN Jingjing¹(), NONG Zhangsong², TAN Liangyuan¹, YANG Peipei², LIANG Yingye², TANG Hongliang³, WANG Kailong²^,^△()

1 Guangxi University of Traditional Chinese Medicine Graduate School, Nanning 530000, China
2 Department of Rehabilitation, the First Affiliated Hospital of Guangxi University of Traditional Chinese Medicine
3 Guangxi University of Traditional Chinese Medicine Affiliated Fangchenggang Hospital

Received:2024-04-02 Revised:2024-05-17 Published:2024-09-15 Online:2024-09-06
Contact: ^△E-mail：13707884976@163.com

陈晶晶, 农章嵩, 谭良源, 杨培培, 梁英业, 唐宏亮, 王开龙. 小胶质细胞极化在神经病理性疼痛中作用研究进展[J]. 天津医药, 2024, 52(9): 1000-1003.

CHEN Jingjing, NONG Zhangsong, TAN Liangyuan, YANG Peipei, LIANG Yingye, TANG Hongliang, WANG Kailong. Research progress on the role of microglia polarization in neuropathic pain[J]. Tianjin Medical Journal, 2024, 52(9): 1000-1003.

摘要/Abstract

摘要：

神经病理性疼痛（NPP）是一种反复且难以治愈的疼痛综合征，小胶质细胞极化与其有密切联系。小胶质细胞极化后可形成M1促炎型与M2抗炎型，M1型与M2型小胶质细胞通过调控炎症反应参与NPP。M1促炎型通过促炎因子和有害物质的释放在NPP中起到伤害作用；而M2抗炎型与之相反，通过分泌抗炎因子起到保护作用。就小胶质细胞极化对NPP作用的研究进展进行综述。

关键词: 小神经胶质细胞, 炎症, 极化, 神经病理性疼痛

Abstract:

Neuropathic pain (NPP) is a recurrent and intractable pain syndrome, and microglial polarization is closely related to it. Recent studies have shown that after cell polarization, M1 pro-inflammatory and M2 anti-inflammatory types could be formed, and M1 and M2 microglial cells are involved in NPP through the modulation of inflammatory responses. The two types of microglial cells have different roles in NPP, just like a double-edged sword. M1 pro-inflammatory type plays an injurious role in NPP through the release of pro-inflammatory factors and noxious substances, whereas M2 anti-inflammatory type plays a protective role by secreting anti-inflammatory factors. In this article, the role of microglia polarization on NPP are reviewed.

Key words: microglia, inflammat ion, polarization, neuropathic pain

中图分类号:

R741

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小胶质细胞极化在神经病理性疼痛中作用研究进展

Research progress on the role of microglia polarization in neuropathic pain

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