Abstract: Abstract:Objective To compare the clinical effects between uniportal video-assisted thoracic surgery (VATS) and 3- portal VATS lobectomy for patients with lung cancer. Methods Patients were divided into uniportal VATS lobectomy group (n=45) and 3-portal VATS lobectomy group (n=53). The clinical data were compared between two groups, including the oper⁃ ation time, intraoperative blood loss, number of lymph node dissection, length of incision, postoperative extubation time, post⁃ operative pain score and postoperative hospitalization. Results There were no significant differences in intraoperative blood lose (128.75±18.32) mL vs (129.15±17.69) mL, lymph node dissection number (13.33±1.05) vs (13.12±1.38), duration of chest drainage (4.90±0.75)d vs (4.75±0.70)d, duration of hospital stay (7.52±1.16)d vs (7.55±1.10)d and incidence of seri⁃ ous postoperative complications between two groups (P>0.05). The incision length (5.36±0.22)cm vs (7.44±0.35)cm, numeric pain intensity scale including first day(6.47±0.54) vs (6.86±0.52)， third day(3.59±0.29) vs (4.05±0.25), and patient satisfac⁃ tion scores (91.03±2.62) vs (88.35±2.97) were significantly better in uniportal VATS group than those of 3-portal VATSgroup (P<0.05). The operation time (143.81±17.97) min vs （130.11±15.03） min was longer in uniportal VATS group than that of 3-portal VATS group (P < 0.05). Conclusion Uniportal VATS lobectomy is safe and reliable for patients with early- stage lung cancer, which has less surgical injury, slighter pain, and higher satisfaction than 3-portal VATS lobectomy.

Key words: pneumonectomy, thoracoscopy, uniportal VATS;3-portal VATS, lobectomy, lung cancer