Abstract: Abstract: Circular RNA (circRNA) is a class of non- coding RNA that assumes a covalently closed continuous conformation. Recent studies have revealed that circRNAs are stable and widely expressed, and often exhibit cell typespecific or tissue-specific expressions. Emerging evidence indicates that some circRNAs can serve as microRNA (miRNA)sponges, regulate transcription or splicing, and can interact with RNA binding proteins. Moreover, circRNAs have been reported to play essential roles in myriad life processes, such as aging, insulin secretion, tissue development, atherosclerotic vascular disease, cardiac hypertrophy and cancer. Here, we review the current understanding of circRNA classification,function and significance in some cardiovascular diseases.

Key words: circular RNAs, noncoding RNAs, microRNAs sponge, transcription, cardiovascular diseases