Abstract: Objective To observe the curative effect of plasma perfusion (PP) combined with continuous veno-venous hemofiltration (CVVH) on different degrees of paraquat poisoning induced acute lung injury (ALI), and assess its clinical value for treatment of paraquat poisoning. Methods Data of 197 patients with paraquat poisoning hospitalized in our hospital from June 2013 to April 2017 were retrospectively analysed, including 128 cases with mild-to-moderate poisoning (5 mg·h/L≤SIPP≤25 mg·h/L) and 69 cases with severe poisoning (25 mg·h/L＜SIPP≤50 mg·h/L). Patients were divided into treatment group and control group according to the treatment of PP and CVVH. The incidence rate and time of irreversible lung injury were compared between the two groups of patients. Results (1) In patients with mild-to-moderate poisoning, the incidence rate of lung injury was significantly lower in treatment group than that of control group (P < 0.05). In patients with severe poisoning there was no significant difference in the incidence rate of lung injury between two groups (P > 0.05). (2) There was no significant difference in the occurrence time of irreversible lung injury between two groups of patients with different degrees of poisoning (P > 0.05). (3) The blood toxicant concentration of 4.35 mg·h/L and SIPP value 19.35 mg·h/L were used as a critical indicator of prognosis in treatment group. Conclusion Plasma perfusion combined with continuous veno-venous hemofiltration can obviously reduce the incidence of paraquat poisoning of lung injury in mild-to-moderate patients, but which has no obvious influence on the occurrence time.

Key words: paraquat, poisoning, plasma perfusion, hemofiltration, acute lung injury