Abstract: Abstract: Objective To investigate the relationship between epicardial adipose volume (EATV) and the severity and prognosis of coronary atherosclerosis. Methods The clinical data of 170 patients underwent percutaneous coronary intervention (PCI) and 58 patients without coronary artery stenosis were analyzed. Patients who accepted PCI were divided into low score group (n=108), middle score group (n=30) and high score group (n=32) according to Gensini score system. Data of EATV were evaluated. The differences in clinical data were analyzed between groups. Gensini scores and the number of diseased vessels in patients were observed by Pearson’s method, and receiver operating characteristic curve (ROC) were used to evaluate the value of EATV in the prognosis of PCI. Results The body mass index (BMI), primary diseases (hypertension and diabetes), triglyceride (TG), low density lipoprotein (LDL-C) and EATV were significantly higher in the coronary heart disease patients than those of patients with non-coronary heart disease (P＜0.05). There were significant differences in LDL-C and EATV between the low, middle, and high Gensini groups (P＜0.05), in which the LDL-C level and EATV level were significantly higher in high Gensini group than those of other two groups (P＜0.05). There were significant differences in the number of diseased vessels between three groups (P＜0.05). EATV was positively correlated with Gensini score (r=0.853, P＜0.05). The relationship between the number of diseased vessels and EATV was three or more lesions>two-vessel disease>single-vessel disease (P＜0.05). One years after PCI, the incidence of new coronary artery lesions was 10%. EATV was higher in these patients than that of patients without new coronary artery disease (P＜0.05). The area under the ROC curve was 0.626 (95% CI: 0.512 - 0.740), the sensitivity was 88.2%, the specificity was 40.5%, and cutoff value was 124.70 cm3. Conclusion EATV is positively correlated with the severity of coronary arteriosclerosis, which can be used as a reference for diagnosis. When EATV is greater than 124.70 cm3 the incidence of neovascularization increases in patients within 1 year after PCI.

Key words: coronary disease, prognosis, epicardium adipose tissue volume, gensini score