Progress in study on placenta-specific microRNAs and the pathogenesis of preeclampsia

doi:10.11958/20180189

Tianjin Med J ›› 2018, Vol. 46 ›› Issue (8): 890-893.doi: 10.11958/20180189

Previous Articles Next Articles

Progress in study on placenta-specific microRNAs and the pathogenesis of preeclampsia

LIU Jiao1,2 , LIU Guo-long2 , GUO Zheng-chen2 , ZHANG Yun-shan3

1Department of Gynecology and Obstetrics, Binhai Hospital, Tianjin Medical University General Hospital, Tianjin 300480, China; 2 Tianjin Medical University; 3 Tianjin Central Hospital of Gynecology Obstetrics

Received:2018-02-01 Revised:2018-04-28 Published:2018-08-15 Online:2018-08-23

LIU Jiao1,2,LIU Guo-long2,GUO Zheng-chen2,ZHANG Yun-shan3. Progress in study on placenta-specific microRNAs and the pathogenesis of preeclampsia[J]. Tianjin Med J, 2018, 46(8): 890-893.

Abstract

Abstract: Preeclampsia, one of the pregnancy specific diseases, is a leading cause of new onset hypertension and proteinuria after 20 weeks. The preeclampsia pathogenesis includes abnormal placentation and maternal inflammatory response. MicroRNAs are a kind of non-coding RNAs that induce post-transcriptional suppression of target gene expression. In biomedical research, microRNAs can be used as the potential biomarkers to assess the development and prognosis of diseases. Whether the abnormal expression of placental-derived microRNAs is closely related to the occurrence and development of preeclampsia is still controversial. This article reviews the relationship between placental microRNAs and pathogenesis of preeclampsia.

Key words: eclampsia, microRNAs, placenta, biological markers, preeclampsia

[1]	YANG Xiaofang, JIA Xinyan, FENG Wenjun. MiR-181a-5p regulates the proliferation and apoptosis of glomerular mesangial cells in lupus nephritis mice through HMGB1/NF-κB signaling pathway [J]. Tianjin Medical Journal, 2026, 54(3): 232-237.
[2]	CUI Huan, GAO Ying, YANG Junjuan, GUO Ying, YE Qing. Expression levels and clinical significance of miR-1227-3p and miR-212-3p in serum and placenta in puerperas with fetal growth restriction [J]. Tianjin Medical Journal, 2025, 53(7): 709-713.
[3]	ZHOU Meijuan, MIAO Xiaoxiang. Relationship between serum expression levels of miR-214-3p and miR-124-3p and the severity of disease in patients with Parkinson's disease and their values in early diagnosis [J]. Tianjin Medical Journal, 2025, 53(5): 498-502.
[4]	SHI Jun, YANG Guilan, YANG Xiaoli. The diagnostic value of uterine spiral artery ultrasound combined with serum CTRP6 and sTWEAK for early-onset preeclampsia [J]. Tianjin Medical Journal, 2025, 53(5): 514-518.
[5]	HU Limei, LIU Huiying, CHEN Yaru, ZHAO Panpan, GU Jun, REN Weidong. Clinical efficacy of caragliflozin and empagliflozin in obese patients with type 2 diabetes mellitus [J]. Tianjin Medical Journal, 2025, 53(10): 1071-1076.
[6]	XIAO Xiaoli, XIE Yao, LONG Zhi. Changes and clinical significance of serum miR-155 and miR-205-5p expression levels in patients with hepatitis C virus infection [J]. Tianjin Medical Journal, 2024, 52(9): 967-970.
[7]	SHENG Hongna, FAN Zhuoran, HUA Shaofang, ZHANG Junnong. Preliminary study on the value of circulating PLGF level in predicting the severity of preeclampsia and evaluating pregnancy outcome [J]. Tianjin Medical Journal, 2024, 52(6): 630-634.
[8]	ZHANG Liran, ZHAO Yanhua. The predictive value of MP hypertension monitoring system combined with PLGF and PI for preeclampsia [J]. Tianjin Medical Journal, 2024, 52(3): 306-310.
[9]	MIAO Chunbo, XU Yingchun, CHANG Yifang. Phlorizin allevistes oxidative stress and apoptosis of rat cardiac myocytes H9C2 induced by hypoxia/reoxygenation by down-regulating miR-125a-5p [J]. Tianjin Medical Journal, 2024, 52(12): 1233-1238.
[10]	CAO Junyang, MA Chunxing, LIU Zhina. Predictive value of vitamin and folic acid levels in gestational diabetes mellitus complicated by preeclampsia [J]. Tianjin Medical Journal, 2024, 52(12): 1278-1282.
[11]	WU Meina, DAI Weizheng, PAN Yudun, FU Maolin, CHEN Xiaoyu. Clinical value of routine electroencephalogram combined with serum miR-146a and miR-129-5p levels in diagnosis of drug-resistant epilepsy patients [J]. Tianjin Medical Journal, 2024, 52(11): 1207-1210.
[12]	LIU Guiying, LIU Lizhi, YANG Zongmei. Relationship between placental growth factor and ultrasonic blood flow parameters in patients with late-onset preeclampsia and its effect on pregnancy outcome [J]. Tianjin Medical Journal, 2024, 52(10): 1069-1074.
[13]	DENG Qianbao, ZHANG Zhongxia, WANG Ru, XU Lin, LUO Shu. Efficacy analysis of a preeclampsia risk prediction model based on exosomal multiple miRNA expression levels [J]. Tianjin Medical Journal, 2024, 52(1): 91-96.
[14]	HOU Yongbo, YU Junma, ZHU Haijuan. New research progress of exosomes in the treatment of myocardial infarction [J]. Tianjin Medical Journal, 2023, 51(9): 1016-1019.
[15]	YUE Jinjing, ZENG Ying, GUO Xiaopei, DONG Yue, JI Ruonan, PENG Rui, LUO Xiaohua. MiR-155 affects the biological functions of trophoblastic cells through regulating cGMP-dependent kinase 1 and is involved in the mechanism of preeclampsia [J]. Tianjin Medical Journal, 2023, 51(9): 928-934.

Progress in study on placenta-specific microRNAs and the pathogenesis of preeclampsia

Cite this article

PDF (PC)

Knowledge

Abstract

share this article

References

Related Articles 15

Recommended Articles

Metrics

Comments