Abstract: Abstract： Objective To evaluate the safety and short-term outcomes of endoscopic resection in the treatment of early adenocarcinoma of gastroesophageal junction. Methods A total of 166 patients with early adenocarcinoma of gastroesophageal junction were treated by endoscopic submucosal dissection (ESD) from April 2016 to October 2018 in the First Affiliated Hospital of Anhui Medical University. The clinical information, including gender, age, the process of ESD treatment, post-operative pathology and additional surgical treatment were recorded. The risk assessment of lymph node metastasis was carried out according to the indications of eCrua scoring system and scores of endoscopic resection of early gastric cancer respectively. Results Among the 166 patients with early adenocarcinoma of gastroesophageal junction, 146 (88.0%) were cured after ESD, 20 cases (12.0%) were non-curable resection, 9 cases (5.4%) were transferred to perform additional operation. In the non-curable resection group, the proportion of patients with lesion diameter > 30 mm, lesions with ulcer or undifferentiated type was significantly higher than that in the curable resection group (P＜0.05). The average postoperative follow-up time was 15.7 months (3-33 months). During the follow-up period, 1 case showed recurrence and no case of death associated with gastric cancer. After operation, there were 4 cases of eCura C, 2 cases of local residual tumors and 1 case of lymph node metastasis. Conclusion ESD is safe and effective for the treatment of early adenocarcinoma of gastroesophageal junction. The risk of lymph node metastasis can be well assessed by eCura score system according to the postoperative pathological results.

Key words: stomach neoplasms, endoscopic submucosal dissection, lymphatic node metastasis, adenocarcinoma of gastroesophageal junction, curative resection, eCura scoring system