Abstract: Abstract: Intestinal flora is the microflora colonized in the intestine. Intestinal flora microecological balance can be affected by various factors, including living environment, life style, eating habits and drugs. These changes are the pathological basis of many diseases. Increasing evidence shows that intestinal flora including Firmicutes, Proteobacteria, Actinobacteria and Bacteroidetes, can increase the incidence of obesity and type 2 diabetes (T2DM) through immune, metabolic and circadian clock pathways. These researches have become the focus of academic discussion. This article summarizes the relationship between changes in intestinal flora and obesity and T2DM in recent years, in order to further clarify the pathogenesis of obesity and T2DM, and provide some new ideas for finding therapeutic targets.

Key words: enterobacteriaceae, obesity, diabetes mellitus, type 2, glucose metabolism disorders, lipid metabolism disorders