Abstract: The effect of insulin intensive therapy on the outcome of diabetic retinopathy (DR) has been controversial all the time. The famous multicenter, randomized trials such as diabetes control and complications trial (DCCT)/the observational epidemiology of diabetes interventions and complications (EDIC) study and UK prospective diabetes study(UKPDS) have demonstrated that course of intensive therapy can successfully make good glycemic control in the short time and lay a foundation for the prolongation of the progression of DR. However, it has also found that tightening of glucose control can trigger transient progression (early worsening) of diabetic retinopathy in type 1 diabetes mellitus (T1DM) with poor glycemic control. In such studies, multiple daily insulin injection (MDI) was used for intensive therapy instead of continuous subcutaneous insulin infusion (CSII), and the protracted effect of CSII on DR for type 2 diabetes mellitus (T2DM)should be further investigated. Here, we summarized and reviewed the progress of insulin pump therapy in the occurrence and development of diabetic retinopathy.

Key words: diabetic retinopathy, continuous subcutaneous insulin infusion, insulin pump, intensive therapy, reviewretinopathy