Abstract:Ovarian cancer is the most lethal gynaecological cancer. And chemotherapy resistance is one of the main reasons for its poor prognosis. Recently, some natural products have been reported to overcome drug resistance, including flavonoids that are abundant in plants, foods, and are also one of the active ingredients in many traditional Chinese herbal medicines. Because of their characteristics of broad biological activity, high efficiency, low toxicity, good prevention and cure effects on various types of tumors, flavonoids have received extensive attention. Here, we summarize the research and discuss the underlying mechanisms, concluding that these flavonoids do not function as specific regulators of target proteins, but rather as multi-functional agents that negatively regulate the key factors contributing to drug resistance of ovarian cancer.