Abstract: Mesenchymal stem cells (MSCs) are pluripotent stromal cells, which have been proved to have abilities to differentiate into osteoblasts and adipocytes, and play an important role in bone regeneration and repair. Recent studies showed that long non-coding RNA (lncRNA) was differentially expressed in the process of osteogenic differentiation of MSCs, and affected the process of osteogenic differentiation of MSCs in many ways. It also played an important role in regulating the balance of bone metabolism. This paper reviewed the latest research progress of lncRNA in the regulation of osteogenic differentiation of MSCs and provided a new idea for further research on the mechanisms of lncRNA regulating the osteogenic differentiation and bone formation of MSCs.

Key words: mesenchymal stromal cells, RNA, long noncoding, cell differentiation, bone regeneration