Abstract: The regulation of intestinal microecology during pregnancy is affected by multiple factors, which are closely related to maternal nutrition, metabolism and immunity, and are related to a variety of pregnancy metabolic complications, which has a profound impact on the establishment of the offspring intestinal flora and long-term health. This article will review and analyze the changes in the intestinal microbiota during pregnancy, the establishment of the intestinal flora of the offspring and the impact of the changes in the intestinal flora of the common metabolic diseases of pregnancy on the offspring. By improving the intestinal structure and preventing the poor metabolic state during pregnancy, the purpose of preventing health risks of offspring will be achieved.

Key words: pregnancy, gastrointestinal microbiome, pregnancy complications, metabolic diseases, offspring