Correlation between ultrasonographic features and molecular subtypes of early mass-type breast invasive ductal carcinoma

doi:10.11958/20220230

Abstract

Abstract:

Objective To investigate the diagnostic value of ultrasonic signs to molecular typing of early mass-type breast invasive ductal carcinoma by analyzing the correlation between ultrasonographic features and molecular types of early mass-type breast invasive ductal carcinoma. Methods A total of 298 patients with stage Ⅰ-Ⅱ breast cancer who were diagnosed by ultrasonography as mass-type lesions before operation and were confirmed as breast invasive ductal carcinoma by surgical pathology were retrospective included. The differences of ultrasonographic features and molecular subtypes were compared and analyzed. The influencing factors of Luminal type, HER-2 overexpression type and triple-negative type were analyzed by Logistic regression. Results Among 298 patients, 26 cases were Luminal A type, 178 cases were Luminal B type, 54 cases were HER-2 overexpression type and 40 cases were triple negative type. There were significant differences in age of onset, tumor diameter, margin, morphology, internal calcification and posterior echo between patients with different molecular types (P<0.05). There were no significant differences in axillary lymph node metastasis, growth direction, echo and blood flow signal (P>0.05). Irregular shape (OR=1.206, 95%CI: 1.039-1.400, P<0.05) and rough edge (OR=1.490, 95%CI: 1.224-1.814, P<0.05) were independent risk factors for Luminal type. The enhancement in posterior echo was the independent protective factor for Luminal type (OR=0.674, 95%CI: 0.603-0.752, P<0.05). Rough edge was the independent protective factor for HER-2 overexpression type (OR=0.688, 95%CI: 0.564-0.838, P<0.05). Irregular shape (OR=0.820, 95%CI: 0.728-0.923, P<0.05), attenuation in posterior echo (OR=0.714, 95%CI: 0.644-0.792, P<0.05), no change in posterior echo (OR=0.723, 95%CI: 0.662-0.791, P<0.05) and mixed echo in posterior echo (OR=0.790, 95%CI: 0.638-0.978, P<0.05) were independent protective factors for triple-negative type. Conclusion The ultrasonographic features can provide a basis for molecular typing of early mass-type breast invasive ductal carcinoma, which has certain clinical significance.

Key words: breast neoplasms, carcinoma, ductal, breast, early diagnosis, ultrasonography, molecular subtypes

CLC Number:

Figures/Tables 8

Tab. 1 Comparison of age of onset and ultrasonographic characteristics of early mass-type breast invasive ductal carcinoma between different molecular subtypes

Fig.1 Comparison of ultrasonographic two-dimensional gray scale images of early mass-type breast invasive ductal carcinoma between different molecular subtypes

Tab.2 Comparison of age of onset and ultrasonographic characteristics between Luminal type and non-Luminal type

Tab.3 Logistic regression analysis of multivariate factors for ultrasonographic characteristics of Luminal type

Tab.4 Comparison of age of onset and ultrasonographic characteristics between HER-2 overexpression type and non-HER-2 overexpression type

Tab.5 Logistic regression analysis of multivariate factors for ultrasonographic characteristics of HER-2 overexpression type

Tab.6 Comparison of age of onset and ultrasonographic characteristics between triple-negative type and non-triple-negative type

Tab.7 Logistic regression analysis of multivariate factors for ultrasonographic characteristics of triple-negative type

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