Research progress on the role of Nrf2/HO-1 pathway in psoriasis

doi:10.11958/20231583

Abstract

Abstract:

The pathogenesis of psoriasis is complex, so it is very important to explore the pathogenesis for the treatment of psoriasis. The Nrf2/HO-1 pathway has a protective effect on cells and is closely related to physiological and pathological aspects such as oxidative stress, immunity, abnormal proliferation of blood vessels, epidermal imbalance and cell death. Currently, some studies have confirmed that Nrf2/HO-1 pathway may have an inhibitory effect on psoriatic lesion, and it may be involved in psoriasis pathogenesis through multiple pathways. This paper reviews the mechanism of Nrf2/HO-1 pathway in psoriasis and the research progress in the treatment of psoriasis through the intervention of traditional Chinese medicine.

Key words: NF-E2-related factor 2, heme oxygenase-1, psoriasis, traditional Chinese medicine and pharmacy, oxidative stress, cell death

CLC Number:

R758.63

Figures/Tables 1

References 58

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