Relationship between serum Cc16 and CD62E expression levels and the severity of neonatal respiratory distress syndrome and pulmonary ultrasound scores

doi:10.11958/20250321

Abstract

Abstract:

Objective To analyze the relationship between serum levels of Clara cell protein 16 (Cc16), E-selectin (CD62E), the severity of neonatal respiratory distress syndrome (NRDS) and lung ultrasound scores. Methods A total of 200 neonates with NRDS were selected in this study. The severity of the disease was assessed using oxygenation index (P/F). The neonates were divided into three groups: the mild group (46 cases), the moderate group (65 cases) and the severe group (89 cases). The serum levels of Cc16 and CD62E were compared between the three groups. In addition, based on the lung ultrasound scores, neonates were divided into the low-score group (score<12 points, n=127), the medium-score group (score 12-24 points, n=51) and the high-score group (score > 24 points, n=22). The receiver operating characteristic (ROC) curve was used to evaluate the predictive efficacy of the combined detection of serum Cc16, CD62E and lung ultrasound score for severe NRDS. Results Compared with the mild group, the serum levels of Cc16 and CD62E, and lung ultrasound scores were higher in the moderate group and the severe group (P<0.05). Compared with the low lung ultrasound score group, the serum levels of Cc16 and CD62E were higher in the moderate lung ultrasound score group and the high lung ultrasound score groups (P<0.05). Cc16 and CD62E were positively correlated with the severity of NRDS (r_s = 0.679 and 0.680, P<0.01), and they were also positively correlated with lung ultrasound scores (r = 0.692 and 0.685, P<0.01). ROC analysis showed that the combined detection of Cc16, CD62E and lung ultrasound scores had a relatively high diagnostic value for severe NRDS (P<0.05). Conclusion The serum levels of Cc16 and CD62E in NRDS neonates are positively correlated with disease severity and lung ultrasound scores.

Key words: neonborn, respiratory distress syndrome, E-selectin, Clara cell protein 16, lung ultrasound score

CLC Number:

R742.1

Figures/Tables 6

References 19

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组别		n	性别（男/女）		胎龄/周		出生时体质量/kg			分娩方式
组别		n	性别（男/女）		胎龄/周		出生时体质量/kg			剖宫产		自然分娩
轻症组		46	24/22		35.52±1.17		2.79±0.21			39（84.8）		7（15.2）
中度组		65	34/31		35.48±1.17		2.77±0.22			57（87.7）		8（12.3）
重症组		89	50/39		35.49±1.08		2.76±0.22			77（86.5）		12（12.5）
χ²或F			0.307		0.021		0.457			0.195
组别	1 min Apgar 评分/分			5 min Apgar 评分/分		IL-6/（ng/L）		IL-1β/（ng/L）	p（O₂）/mmHg		p（CO₂）/mmHg
轻症组	7.48±1.17			8.61±1.13		159.84±44.21		61.54±21.42	74.16±8.54		46.54±3.58
中度组	6.52±1.09^a			7.60±1.16^a		181.45±47.28^a		75.38±24.33^a	66.33±6.52^a		51.02±5.44^a
重症组	6.12±0.85^ab			6.55±1.15^ab		235.28±51.22^ab		87.51±26.12^ab	52.11±5.02^ab		58.17±6.97^ab
F	27.310^＊＊			50.959^＊＊		44.207^＊＊		17.383^＊＊	200.326^＊＊		66.400^＊＊

组别		n	性别（男/女）		胎龄/周		出生时体质量/kg			分娩方式
组别		n	性别（男/女）		胎龄/周		出生时体质量/kg			剖宫产		自然分娩
轻症组		46	24/22		35.52±1.17		2.79±0.21			39（84.8）		7（15.2）
中度组		65	34/31		35.48±1.17		2.77±0.22			57（87.7）		8（12.3）
重症组		89	50/39		35.49±1.08		2.76±0.22			77（86.5）		12（12.5）
χ²或F			0.307		0.021		0.457			0.195
组别	1 min Apgar 评分/分			5 min Apgar 评分/分		IL-6/（ng/L）		IL-1β/（ng/L）	p（O₂）/mmHg		p（CO₂）/mmHg
轻症组	7.48±1.17			8.61±1.13		159.84±44.21		61.54±21.42	74.16±8.54		46.54±3.58
中度组	6.52±1.09^a			7.60±1.16^a		181.45±47.28^a		75.38±24.33^a	66.33±6.52^a		51.02±5.44^a
重症组	6.12±0.85^ab			6.55±1.15^ab		235.28±51.22^ab		87.51±26.12^ab	52.11±5.02^ab		58.17±6.97^ab
F	27.310^＊＊			50.959^＊＊		44.207^＊＊		17.383^＊＊	200.326^＊＊		66.400^＊＊

组别	n	Cc16/（μg/L）	CD62E/（μg/L）	肺部超声评分/分
轻症组	46	40.44±5.12	19.77±8.03	8.42±1.67
中度组	65	47.51±6.22^a	43.27±12.82^a	12.42±3.55^a
重症组	89	54.41±8.04^ab	58.69±22.11^ab	16.87±5.29^ab
F		62.808^＊＊	80.527^＊＊	65.971^＊＊

组别	n	Cc16/（μg/L）	CD62E/（μg/L）	肺部超声评分/分
轻症组	46	40.44±5.12	19.77±8.03	8.42±1.67
中度组	65	47.51±6.22^a	43.27±12.82^a	12.42±3.55^a
重症组	89	54.41±8.04^ab	58.69±22.11^ab	16.87±5.29^ab
F		62.808^＊＊	80.527^＊＊	65.971^＊＊

组别	n	Cc16	CD62E
低评分组	127	41.02±5.09	28.67±9.58
中评分组	51	46.58±5.57^a	46.81±14.01^a
高评分组	22	55.73±8.19^ab	57.91±21.21^ab
F		139.575^＊＊	74.428^＊＊