Research progress of autophagy in acute respiratory distress syndrome

doi:10.11958/20221782

Abstract

Abstract:

Acute respiratory distress syndrome (ARDS) is a type of respiratory clinical syndrome centered on uncontrolled inflammatory response. As a major pathway to maintain cellular homeostasis, autophagy plays an important regulatory role in the inflammatory response in ARDS. In animal or cellular experiments, it has been confirmed that drug intervention regulates the transduction of signaling pathways such as target of rapamycin (mTOR) and AMP-activated protein kinase (AMPK), thereby regulating autophagy to reduce lung injury. Therefore, regulating autophagy may become an important treatment for ARDS patients. This article reviews the mechanism of autophagy and the role of autophagy in ARDS in alveolar macrophages, neutrophils, alveolar epithelial cells and vascular endothelial cells, in order to provide new reference for the diagnosis and treatment of ARDS, the research and development of autophagy modulators and clinical application.

Key words: autophagy, respiratory distress syndrome, signaling pathway, endoplasmic reticulum stress

CLC Number:

R563.9

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