Evaluation of the effect of benserazide combined with respiratory training on post-stroke dysphagia

doi:10.11958/20241777

Abstract

Abstract:

Objective To investigate the effect of benserazide combined with respiratory training on post-stroke dysphagia. Methods A total of 120 patients with dysphagia after stroke were prospectively selected and randomly divided into the combination group and the breathing exercise group, with 60 cases in each group. The breathing exercise group was treated with rehabilitation breathing training, and the combination group was treated with dopa serazide on the basis of rehabilitation breathing training, 3 times a day, 1 tablet once. The traditional Chinese medicine (TCM) syndrome scores, clinical efficacy and swallowing function indexes including dysphagia angiography score (VDS), osmotic-aspiration scale (PAS) score, Lowada drinking water test score and VFSS score were compared between the two groups. Nutritional indices [total cholesterol (TC), triglyceride (TG), albumin (ALB), hemoglobin (Hb)], related indexes of nerve function [nerve function and serum growth differentiation factor 15 (GDF-15), central nerve specific protein soluble protein-100β (S100β)], quality of life and anxiety disorder score [Quality of Life Rating Scale (SF-36) score, Generalized Anxiety Disorder Scale (GAD-7) score] and adverse reactions were compared between the two groups. Results The total effective rate of the combination group (91.67%) was obviously increased (P<0.05) compared to the breathing exercise group (58.33%). Compared with before treatment, after treatment, tongue flaccidity, slow swallowing, choke after drinking water, tongue coating ecchymosis, score of fine pulse, VDS, PAS, score of Lowada drinking water test, GDF-15 level and GAD-7 score were decreased in the two groups, and those of the combination group were significantly lower than the breathing exercise group (P<0.05). The levels of TC, TG, ALB, Hb, S100β, VFSS and SF-36 were increased in the two groups, and those of the combination group were higher than the breathing exercise group (P<0.05). There was no significant difference in the incidence of adverse reactions between the two groups. Conclusion Benserazide combined with respiratory training has high clinical efficacy in patients with post-stroke dysphagia, which can effectively improve the TCM evidence score and nutritional indicators, improve swallowing function, reduce anxiety, improve quality of life, and have more ideal clinical application.

Key words: stroke, deglutition disorders, breathing exercises, benserazide, effect evaluation

CLC Number:

R969.4

Figures/Tables 8

References 19

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组别	性别（男/女）	年龄/ 岁	体质量指数/ （kg/m²）	病程/ 月
呼吸训练组	26/34	62.92±7.05	18.98±2.49	2.45±0.67
联合组	25/35	64.38±6.31	19.35±2.57	2.30±0.74
χ²或t	0.034	1.201	0.800	1.157

组别	性别（男/女）	年龄/ 岁	体质量指数/ （kg/m²）	病程/ 月
呼吸训练组	26/34	62.92±7.05	18.98±2.49	2.45±0.67
联合组	25/35	64.38±6.31	19.35±2.57	2.30±0.74
χ²或t	0.034	1.201	0.800	1.157

组别	舌痿缩					吞咽缓慢					饮水发呛
组别	治疗前		治疗后	t		治疗前		治疗后		t	治疗前		治疗后		t
呼吸训练组	4.75±0.85		3.65±0.59	8.018^＊		5.17±0.87		4.70±0.57		3.501^＊	4.89±0.86		3.93±0.49		8.895^＊
联合组	4.55±0.52		1.31±0.23	43.773^＊＊		5.46±0.76		2.36±0.25		31.317^＊＊	5.16±0.68		2.55±0.28		28.220^＊＊
t	1.477		28.898^＊＊			0.581		28.839^＊＊			1.965		18.660^＊＊
组别		舌苔瘀斑							脉搏细涩
组别		治疗前			治疗后		t		治疗前			治疗后		t
呼吸训练组		2.19±0.27			1.83±0.19		9.004^＊		2.19±0.25			1.87±0.19		7.351^＊
联合组		2.26±0.34			1.01±0.18		25.503^＊＊		2.13±0.20			1.05±0.12		38.222^＊＊
t		1.140			24.285^＊＊				1.403			27.409^＊＊

组别	舌痿缩					吞咽缓慢					饮水发呛
组别	治疗前		治疗后	t		治疗前		治疗后		t	治疗前		治疗后		t
呼吸训练组	4.75±0.85		3.65±0.59	8.018^＊		5.17±0.87		4.70±0.57		3.501^＊	4.89±0.86		3.93±0.49		8.895^＊
联合组	4.55±0.52		1.31±0.23	43.773^＊＊		5.46±0.76		2.36±0.25		31.317^＊＊	5.16±0.68		2.55±0.28		28.220^＊＊
t	1.477		28.898^＊＊			0.581		28.839^＊＊			1.965		18.660^＊＊
组别		舌苔瘀斑							脉搏细涩
组别		治疗前			治疗后		t		治疗前			治疗后		t
呼吸训练组		2.19±0.27			1.83±0.19		9.004^＊		2.19±0.25			1.87±0.19		7.351^＊
联合组		2.26±0.34			1.01±0.18		25.503^＊＊		2.13±0.20			1.05±0.12		38.222^＊＊
t		1.140			24.285^＊＊				1.403			27.409^＊＊

组别	治愈	显效	有效	无效	总有效
呼吸训练组	7（11.67）	13（21.67）	15（25.00）	25（41.67）	35（58.33）
联合组	12（20.00）	18（30.00）	25（41.67）	5（8.33）	55（91.67）
χ²					17.778^＊＊