Abstract: Objective To compare clinical-pathological features and Ki-67 expression profile between TNBC and Non-triple-negative cancer (NTNBC). Methods The expressions of ER, PR and HER2 were examined by immunohisto⁃ chemical Envision double staining in 226 cases of breast cancer. All cases were divided into triple-negative and non-triplenegative group according to expressions of these three episodes. And Ki-67 expressions in two groups were assessed by im⁃ munohistochemical method. The difference of Ki-67 positive index between these two groups and the difference of Ki-67 positive index between different clinical-pathological features were both analyzed by comparative analysis. Results In pa⁃ tients with TNBC, tumor size, lymph node metastasis rate and Ki-67 index were all significantly higher than that in NTNBC. No significant difference in age and histological grade were detected between these two groups. The expression of Ki-67 was not significant correlated with age, tumor size，lymph node status and histological grade in these two groups. Conclusion Patients with triple-negative breast cancer were with larger tumor size, higher proliferation, more lymph node metastasis and poorer prognosis.

Key words: breast neoplasms, receptors, estrogen, receptor, epidermal growth factor, progesterone, receptor, Ki67