Abstract: ABSTRACT: Objective To investigate the mechanism and the effect of highly permeable dialysis and low permeable dialysis on uremic pruritus. Methods Thirty-eight patients of uremic pruritus studied were randomly divided into observed group and control group. Nineteen cases received high permeable dialysis (observed group) and the others received low permeable dialysis (control group) with three times-weekly session of 4 hours following up one year. All patients were dialyzed with Fresenius 4008S. Blood urea nitrogen(BUN) , creatinine ,phosphate ,β2- microglobulin and parathyroid hormone(PTH) were tested and solute clearance and Kt/ V value was figured out. The degree of skin itch was evaluated by the visual analogue scales (VAS). Results There was no significant difference between observed group and control group in the decrease of BUN ,creatinine(P>0.05). But the decreases of phosphate andβ2-microglobulin of observed group were superior to that of control group, (30.4±14.95) % and (35.12±17.82) % vs (22.06±8.32) % and (1.64±4.93) %(P<0.05) . And there was no difference in Kt/ V value between the two groups(P>0.05) . After one year ,the decrease of PTH of observed group was superior to that of control group (27.54±19.43)pmol/ L vs (43.31±19.59) pmol/ L(P<0.05) and compared to pretreatment ,skin itch was relieved in both groups(P<0.05) ,but observed group was superior to control group , (2.66±1.16) scores vs (5.53±1.56) scores (P<0.05) . Conclusion Compared to low permeable dialysis, highly permeable dialysis,which not only cleared the micromolecule toxins,but increased the clearance of macro-middle molecule toxins,can significantly relieve uremic pruritus.

Key words: highly permeable dialysis, dialysis, uremic pruritus