Abstract: Abstract：0bjective To investigate the changes of the levels of high sensitivity reactive protein C (hsCRP), white blood cell (WBC) and fibrinogen (FIB) in diabetic nephropathy(DN) pa- tients. Methods：The clinic documents of 506 patients with type 2 diabetes were divided into two groups based on with／without DN．The changes of the levels of hsCRP，WBC and FIB in the two groups and the relationship between their levels and DN were analyzed．Results:Compared to non-DN group，the levels of hsCRP，WBC，FIB in DN group were increased obviously（3.653±4.634vs1.974±2.878; 7.04±1.94vs6.49±1.65; 3.46±0.89vs3.16±0.72,P<0.05）.Using univariate logistic regression analysis it was found that the nephropathy had a positive correlation with WBC，hsCRP，FIB（OR=1.127, 95%CI：1.072-1.186；OR=1.188, 95%CI：1.072-1.317;OR=1.630, 95%CI：1.284-2.070）.In a multiple logistic regression analysis，after adjusting the age，gender，the ascend duration of diabetes，smoking , blood pressure, lipid and body mass index(BMI)，the levels of WBC，hsCRP，FIB still had a predominant relation with DN(OR=1.163，95% CI：1.034-1.308；OR =1.772，95% CI：1.343-2.338；OR=1.144，95% CI：1.082-1.211). Conclusion :The levels of WBC，hsCRP，FIB are closely related with DN．These subclinical inflammatory index can be used for prognosis and evalutation of DN．

Key words: Diabetes mellitus, type 2, Diabetic nephropathies, Hypersensitivity reactive protein C, Fibrinogen, White blood cell