Abstract: Objective: To investigate the clinical significance of oxidized low-density lipoprotein, endothelin-1 and nitric oxide in pregnant woman with pre-eclampsia.Methods: From June 2008 to January 2009 ,59 woman with hypertension who delivered in the department of Obstetrics, The Second Hospital of Tianjin Medical University, were recruited,including 20 women with mild pre-eclampsia.(MPE group) and 19 women with severe pre-eclampsia.(SPE group).and 20 healthy pregnant women were taken as control group. Enzyme –linked immunosorbent assay（ELISA）was used to measure the oxLDL and ET-1 level in these women. Nitrate reduction was used to measure the NO level in the plasma and investigate the correlation of them. Results: the oxLDL level in MPE group (10.06±3.61)mg/L, SPE group (13.25±3.15)mg/L,were significantly higher compared with control group (3.77±0.71)mg/L (both P﹤0.01).(2) the plasma concentrations of oxLDL 、ET-1 and NO in healthy pregnant women group were (3.77±0.71)mg/L、(1.15±0.35)ng/L、(58.4±9.80)μmol/L. the oxLDL level has no obvious correlation with ET-1、NO、SBP and DBP（all P＞0.05）.(3) the plasma concentrations of oxLDL 、ET-1 and NO in mild pre-eclampsia. (MPE group) were (10.06±3.61)mg/L、(2.47±0.73)ng/L、(34.8±5.70)μmol/L。the oxLDL level has obvious correlation with ET-1 and NO (r=0.572、0.619, both P﹤0.01）. the oxLDL level has obvious correlation with SBP and DBP (r=0.516、0.691,both P<0.01). (4) the plasma concentrations of oxLDL、ET-1 and NO in severe pre-eclampsia(SPE group) were (13.25±3.15)mg/L、(3.19±0.67)ng/L、(25.1±3.80)μmol/L. the oxLDL level has obvious correlation with ET-1、NO、SBP and DBP(r=-0.529、-0.598、0.474、0.537，all P<0.01).Conclusion : oxLDL in plasma may be involved in the pathophysiological processes of pre-eclampsia by affecting the endothelial systolic and diastolic factors'expression such as ET-1 and NO. And closely related to the incidence of pre-eclampsia.

Key words: pre-eclampsia, oxidized low-density Lipoprotein, endothelin-1, nitric oxide